Macomics is a UK-based start-up focused on the development of novel, first-in-class immunotherapies designed to modulate macrophages, increasing the body’s immune defence against tumours.
Macomics’ approach is based on leading academic research around macrophage biology, particularly in cancer, from the laboratory of Professor Jeffrey Pollard, Director of the MRC Centre for Reproductive Health at the University of Edinburgh, working with co-founder Dr Luca Cassetta.
Cancer cells are known to be able to evade destruction by the immune system and tumour associated macrophages (TAMs) are a key component of this immuno-suppressive and pro-tumoral ecosystem. Modulating TAMs will alter the tumour microenvironment enhancing the body’s ability to fight cancer. Using its proprietary technology, Macomics says it has identified novel targets that are highly upregulated in TAMs compared to other cell types, providing an opportunity to selectively target the tumours.
Approach: Modulation of macrophages.
Indications: Cancer (various).
Stage: Discovery
The company raised seed funding of £3.2M (USD 4M) in mid-2020 to develop its tumour-associated macrophage target discovery platform and pipeline.
Subscribe for alerts on new companies featured on Startups.Bio
- Cytospire TherapeuticsFounded in 2023, Cytospire Therapeutics is developing a portfolio of next-generation immune… Read more: Cytospire Therapeutics
- This Week in Biotech Venture CapitalThe biotech sector continues to see a strong flow of new venture… Read more: This Week in Biotech Venture Capital
- THRONCATTHRONCAT is a new startup that aims to transform the field of… Read more: THRONCAT
- Roundup of recent venture funding roundsThe biotechnology sector is advancing rapidly, fueled by significant venture capital investments… Read more: Roundup of recent venture funding rounds